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Schematic representing a) the macromolecular organization of hyaluronan (HA), aggrecan and link protein (LP); b) the involvement of link protein in the interaction between the G1 domain of the aggrecan core protein with a hyaluronan binding region; and c) the triple hairpin structure of link protein, held together by disulfide bonds, and the N-terminal cleavage product Link-N peptide.
