Table 2.

The calculated dissociation constants (K _d) and binding affinity constants (τ) of glucagon-like peptide-1 (GLP-1) with its receptor at the cardiomyocytes (N = 8).

Rat group	K d (moles × 10−15)	τ (min)
Normal (N)	0.64 ± 0.021a	0.34 ± 0.005a′
Diabetic (D)	0.33 ± 0.018b	0.6 ± 0.018b′
Diabetic + Insulin (DI)	0.47 ± 0.019c	0.43 ± 0.009c′
Diabetic + Exendin-4 (DE)	0.59 ± 0.025d	0.41 ± 0.0084d′
Diabetic + Aliskiren (DA)	0.12 ± 0.014e	1.37 ± 0.0938e′
Diabetic + Exendin-4 + Aliskiren (DEA)	0.077 ± 0.01f	1.63 ± 0.13f′
Diabetic + Insulin + Aliskiren (DIA)	0.19 ± 0.027g	1.33 ± 0.08g′

Cardiomyocytes: dissociation constants significant at P < .05 for (b, c), (b, g), (c, d), (e, f), (f, g) and P < .001 for (a, b), (a, c), (a, e), (a, f), (a, g), (b, d), (b, e), (b, f), (c, e), (c, f), (c, g), (d, e), (d, f), (d, g), (f, g). The other comparative values are not significant (P > .05). Binding affinities significant at P < .001 for (a′, b′), (a′, c′), (a′, d′), (a′, e′), (a′, f′), (a′, g′), (b′, c′), (b′, d′), (b′, e′), (b′, f′), (b′, g′), (c′, e′), (c′, f′), (c′, g′), (d′, e′), (d′, f′), (d′, g′). The other comparative values are not significant (P > .05).