Figure 5.

1D11 treatment increases the number of activated satellite cells in mdx mice. The numbers of myogenin-positive nuclei in diaphragm and soleus muscles treated from 2 weeks to 9 months of age with 1D11 (n = 9) were significantly greater than those from vehicle-treated mdx mice (n = 8). In mice treated with losartan alone or in combination with 1D11 (n = 9, each group), the number of myogenin-positive satellite cells was also increased, but not as much as with 1D11 alone. Data are reported as means ± SE. Statistical analyses were by analysis of variance followed by Dunnett's multiple comparison test relative to vehicle control. *P < 0.001 and **P < 0.01 versus vehicle control.