Figure 2.

Liver morphology and inflammation in adiponectin-deficient and transgenic mice. Liver fibrosis was induced with repetitive intraperitoneal injection of 0.2 g/kg body weight of thioacetamide. At the end of the experimental period, liver samples were collected for histological and biochemical assays. A: Representative images of liver sections stained with H&E. Areas in insets are shown in higher magnification in the bottom row. Scale bars = 50 μm. B: mRNA was isolated from liver tissue, and relative abundance of F4/80 mRNA levels was measured by RT-PCR (means ± SE; n = 4). *P < 0.05 versus WT; **P < 0.05 versus KO.