Figure 8. Evidence for regulatory CA30 T cells in the periphery of CA30/κTg^low BM chimeras.

A, High frequency of CA30 T cells express CD25 and Foxp3. B, Mean frequencies and SEM of Foxp3⁺ cells among CD4⁺ Thy1.1⁺ Vβ8⁺ splenocytes (n=9, combined results of 3 experiments). C, CD4⁺ CD25⁺ CA30 T cells from CA30/κTg mice inhibit proliferation of CA30 T cells to Vκ36–71 FR1 peptide. CD4⁺ CD25⁺ CA30 T cells were mixed with naive CFSE-labeled CA30 T cells at indicated ratios and cultured for 7d with Vκ36–71 FR1 peptide and APC (n=3). Non proliferating CA30 T cells were determined in cultures without peptide and CD4⁺ CD25⁺ CA30 T cells. One of 2 experiments with similar results.