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. 2011 Jun;178(6):2920–2930. doi: 10.1016/j.ajpath.2011.02.019

Figure 2.

Figure 2

Greater perivascular cell proliferation in LLC tumors after AX102. Confocal microscopic images of blood vessels (CD31, green) and apoptotic cells (activated caspase-3, red) in LLC tumors with widths of sleeve of nonapoptotic tumor cells around tumor vessels measured from vessel to region of activated caspase staining (A). The sleeve of nonapoptotic tumor cells was significantly wider after AX102 for 14 days than after vehicle (A, graph). Fluorescent micrographs illustrating conspicuously more proliferating cells (PHH3, red) around blood vessels (CD31, green) in LLC tumors treated for 14 days with AX102 than with vehicle (B). The area density of PHH3 staining was significantly greater after AX102 (B, graph). *P < 0.05 compared to vehicle. Scale bars: 50 μm (A), 100 μm (B).