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. 2011 Jun;178(6):2920–2930. doi: 10.1016/j.ajpath.2011.02.019

Figure 5.

Figure 5

Greater efficacy of CTX on LLC tumors when given together with AX102. Confocal microscopic images of proliferating cells (PHH3, red) and hypoxic regions (pimonidazole, green) in LLC tumors treated with vehicle, 20 mg/kg CTX, or 105 mg/kg CTX on days 14 to 20 together with vehicle or AX102 on days 0 through 20 (A). Proliferating cells were more numerous in nonhypoxic regions of tumors than in hypoxic regions marked by pimonidazole (A). PHH3 staining was reduced significantly by treatment with 20 mg/kg CTX when accompanied by AX102 but not when accompanied by vehicle (A and B). PHH3 staining was reduced even more by a high dose of CTX (105 mg/kg), but the reduction was not augmented by the addition of AX102. Tumor weights were reduced by CTX in a dose-dependent manner (C). P < 0.05 compared to *vehicle + vehicle or †vehicle + AX102. Scale bar = 75 μm.