Skip to main content
. 2011 Jun;178(6):2802–2810. doi: 10.1016/j.ajpath.2011.02.042

Figure 2.

Figure 2

Placental pathology after mild maternal immune challenge at E12.5. A–C: Placentas were harvested from pregnant mice 24 hours after E12.5 saline or LPS treatment. Placentas show typical dark areas of hemorrhage in LPS-challenged pregnancies. Scale bar = 1 cm. D: Dark-field image of a saline mouse placental cross section showing reflective red blood cells (yellow) within the umbilical cord (UC) and labyrinth layer where the maternal-fetal blood exchange occurs. The spongiotrophoblast (Sp) layer appears darker. Scale bar = 100 μm. E–J: Uteri and placentas were harvested from pregnant mice at 6 hours or 24 hours after E12.5 treatment with saline or LPS (60 or 100 μg/kg). Vascular engorgement is visible in placentas stained with H&E at 6 hours (F and G) or 24 hours (E and H–J) after LPS treatment (60 μg/kg) within the labyrinth (Lab) layer. Tracts of eosinophilic necrotic tissue are also seen within the spongiotrophoblast (Sp) layer 24 hours after LPS challenge, indicated by arrows (E) and a boxed area (I), which is shown also at higher magnification (J). Yellow dotted lines mark the border between the spongiotrophoblast and labyrinth layers. Scale bar = 100 μM (E). Original magnification: ×10 (E); ×100 (F–I); ×400 (J).