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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: J Immunol. 2011 Jan 5;186(3):1575–1588. doi: 10.4049/jimmunol.1002990

Figure 5. Patr-AL and HLA-A*0201 (1HHK) but not HLA-B*0801 (1M05) share binding site architecture despite non-conservative changes in specificity-determining pockets B and F.

Figure 5

The architecture of (A) the B pocket and (B) the F pocket in the structures of Patr-AL, HLA-A*0201 (1HHK) and HLA-B*0801 (1M05) in complexes with peptide are compared. Peptide is shown in red. Top panels, stick representations of side chains forming the pockets are shown in gray; bottom panels, molecular surfaces of the pockets are shown. Residues and approximate positions of the B and F pockets are indicated.