Table 2.
Characteristics of CHC Patients with Electron Microscopy Analysis, LC3 Immunoblotting or LC3A and LC3B mRNA Assessment
| Patients with electron microscopy analysis (n = 23) | Patients with LC3 immunoblotting (n = 15) | Patients with LC3A and LC3B mRNA assessment (n = 10) | Patients with LAMP2 immunoblotting (n = 8) | |
|---|---|---|---|---|
| Sex (male) | 15 (65) | 11 (73) | 4 (40) | 5 (63) |
| Age (years) | 48 (23–74) | 48 (20–74) | 51 (33–66) | 57 (33–69) |
| Body mass index (kg/m2) | 24.7 (19.0–36.4) | 25.3 (17.3–34.8) | 24.7 (20.5–36.3) | Not available |
| Serum levels at liver biopsy | ||||
| AST (×ULN) | 1.7 (0.7–6.2) | 1.4 (0.7–7.1) | 2.1 (0.9–5.4) | 1.8 (0.8–2.7) |
| ALT (×ULN) | 2.2 (0.6–8.4) | 1.9 (0.8–9.4) | 2.7 (1.1–5.6) | 2.3 (1–4.3) |
| γ-GT (×ULN) | 1.5 (0.2–4.7) | 1.8 (0.4–5.9) | 1.8 (0.3–5.3) | Not available |
| Total cholesterol (mmol/L) | 4.7 (2.5–7.2) | 4.4 (2.9–6.5) | 4.5 (3.1–5.1) | Not available |
| Triglycerides (mmol/L) | 1.1 (0.4–3.7) | 0.9 (0.5–1.8) | 1.3 (0.5–1.8) | Not available |
| Glucose (mmol/L) | 5.5 (4.2–16.3) | 5.1 (3.4–7.2) | 5.0 (3.8–6.4) | Not available |
| HCV RNA (log) | 6.06 (4.94–7.77) | 6.39 (4.37–7.38) | 6.11 (5.79–7.17) | Not available |
| HCV genotype (1-2-3-4) | 10-2-7-4 | 11-2-1-1 | 5–0-5–0 | 5-0-1-0 (two not availables) |
| Histological analysis | ||||
| Activity grade | 0-9-11-3 | 0-9-5-1 | 0-6-3-1 | 1-5-2–0 |
| (METAVIR A0, A1, A2, A3) | ||||
| Fibrosis stage | 8-6-3-6 | 9-3-1-2 | 3-2-2-3 | 3-4-1–0 |
| (METAVIR F1, F2, F3, F4) | ||||
| Steatosis (% of hepatocytes) | 20 (0–40) | 10 (0–90) | 45 (0–75) | 15 (0–80) |
Data are median (range) or frequency (%).
Fibrosis stage (METAVIR): F0 (absent); F1 (portal fibrosis), F2 (portal fibrosis with few septa), F3 (septal fibrosis), F4 (cirrhosis).
Necroinflammation grade (METAVIR): A0 (absent), A1 (mild), A2 (moderate), A3 (severe).
For ALT level, upper limit of normal is 34 IU/L in women and 45 IU/L in men. For AST level, upper limit of normal is 31 IU/L in women and 35 IU/L in men. For γ-GT level, upper limit of normal is 38 UI/L in women and 55 UI/L in men.
γ-GT, γ-glutamyl transferase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CHC, chronic hepatitis C; LAMP2, lysosome-associated membrane protein 2; LC3, light chain 3; ULN, upper limit of normal.