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. 2011 Jun;178(6):2783–2791. doi: 10.1016/j.ajpath.2011.02.016

Figure 4.

Figure 4

Treatment with an AhR antagonist does not prevent UVB-induced suppression of ova-specific CD8 T-cell (Tc) responses and DTH. A: Mice were topically treated with the AhR antagonist, α-naphthoflavone (α-naph), 30 minutes before each UV irradiation. Splenic CD44hi tetramer (Tet)–positive CD8 T cells were examined 7 days after immunization. The total number and the percentage of CD8 T cells are shown. B: The percentage-specific lysis from an in vivo cytotoxicity assay was determined 7 days after immunization in mice given base lotion or α-naph. C: The DTH reaction from mice 7 days after immunization; mice were unirradiated with base (NoUV), UV irradiated with base (UV), unirradiated with α-naph (NoUVα), and UV irradiated with α-naph (UVα). Data represent a pool of three to four repeat experiments (n = 9 to 12 mice per group) and are given as mean ± SEM. Comparisons between control UV irradiated versus unirradiated or α-naph UV irradiated versus unirradiated are shown. *P < 0.05, **P < 0.01, and ***P < 0.001.