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. 2011 Jun;178(6):2783–2791. doi: 10.1016/j.ajpath.2011.02.016

Figure 5.

Figure 5

Antioxidant treatment can protect a DTH but does not reverse the inhibition of ova-specific CD8 T-cell (Tc) activation caused by UVB. A: Two hours before each UV irradiation, mice were treated with vitamin E and butylated hydroxytoluene (AntiOx) in olive oil i.p. Control mice were given olive oil only. The total number and the percentage of CD44hi tetramer (Tet)–positive CD8 T cells in spleens 7 days after immunization are shown. B: The percentage-specific lysis from an in vivo cytotoxicity assay in mice administered antioxidants or olive oil before UVB. C: The DTH reaction from mice 7 days after immunization; mice were unirradiated with olive oil (NoUV), UV irradiated with olive oil (UV), unirradiated with antioxidants (NoUVAO), and UV irradiated with antioxidants (UVAO). Data represent a pool of three to four repeat experiments (n = 9 to 12 mice per group) and are given as mean ± SEM. Comparisons between control UV irradiated versus unirradiated or antioxidant UV irradiated versus unirradiated are shown. *P < 0.05, **P < 0.01, and ***P < 0.001.