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Incidence of SEB-induced mortality in HLA-DR3 transgenic mice with and without d-galN sensitization. Twelve- to 14-week-old HLA-DR3 transgenic mice (6 to 11 mice per group) were treated as indicated. Mice were monitored once every 3 hours through 9 hours, and daily thereafter. Survival curves and statistical significance were generated using PRISM software (version 3.0a; GraphPad Software Inc., San Diego, CA).
