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Serum biochemical changes in HLA-DR3 transgenic mice undergoing SEB-induced TSS with and without d-galN sensitization.Twelve- to 14-week-old HLA-DR3 transgenic mice were challenged as indicated. Groups of mice (three or four mice per group) were sacrificed at indicated times. Serum ALT, AST, and creatinine concentrations were determined in serum samples pooled from each group. The entire experiment was repeated at least three times, with similar results.
