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. 2011 Jun;178(6):2760–2773. doi: 10.1016/j.ajpath.2011.02.033

Figure 3.

Figure 3

Temporal changes in systemic cytokine levels during SEB-induced TSS. Twelve- to 14-week-old HLA-DR3 transgenic mice were challenged as indicated. Groups of mice (four to six mice per group) were sacrificed at indicated times, and serum cytokine levels were determined using a multiplex suspension array system (Bio-Plex; Bio-Rad Laboratories, Inc., Hercules, CA). Bars represent mean ± SE values for four to six mice. Unpaired Student's t-test was used to determine statistical significance using PRISM software (version 3.0a; GraphPad Software Inc., San Diego, CA). *P < 0.05 with 10 and 50 µg SEB; †P < 0.05 with 50 µg SEB; ‡P < 0.05 with 10 µg SEB.