Figure 2.

The status of oncogenic signaling pathway activities analyzed in the benign nevi, primary melanoma, and metastatic melanoma samples. Within the heat map, columns represent samples; and rows, the oncogenic signaling pathway analyzed. Pathway activities on a low to high continuum are represented by a blue to red continuum, respectively. The color bar below the heatmap defines the sample in each column. The samples are ordered according to the defined subgroups, as shown in Figure 1 (the array tree above the heat map defines the subgroups of melanoma samples exhibiting similar gene expression patterns). CAT indicates catenin; EGFR, epidermal growth factor receptor; ER, estrogen receptor; HER, 2 human epidermal growth factor receptor 2; PI3k, phosphatidylinositol 3-kinase; PR, progesterone receptor.