Figure 3.

Statistically significant differences in the distribution of activities of particular oncogenic signaling pathways identified between subgroups of melanoma samples. A: Oncogenic signaling pathways, as indicated, determined to exhibit statistically significantly distinct levels of activity between the two primary melanoma subgroups (P1 and P2). B: Oncogenic signaling pathways, as indicated, determined to exhibit statistically significantly distinct levels of activity among the three metastatic melanoma subgroups (M1, M2, and M3). Relevant sections of the heat map from Figure 2 are reproduced. The differences in the distribution of activities of particular oncogenic signaling pathways within samples composing one subgroup of melanomas compared with another subgroup of melanomas, as indicated, were quantified with a Mann-Whitney U-test. CAT indicates catenin; EGFR, epidermal growth factor receptor; ER, estrogen receptor; STAT3, signal transducer and activator of transcription.