A functional, VSV-G-tagged version of PcrG (PcrG(i3VG)) was used to determine the localization of PcrG in the cell. Bacteria were fractionated using the lysozyme/EDTA method. Fractions are indicated above each lane (wc = whole cell, S = supernatant, C = cytoplasm, P = periplasm, M = membrane). Fractionation was controlled using markers for secreted proteins (PcrV), membrane proteins (OprH), periplasmic proteins (beta-lactamase) and the cytoplasm (RpoA).