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. Author manuscript; available in PMC: 2011 Jun 27.
Published in final edited form as: Mol Microbiol. 2010 Feb;75(4):924–941. doi: 10.1111/j.1365-2958.2009.07027.x

Fig. 9. Model of PcrV function in type III secretion regulation.

Fig. 9

We propose that the T3SS is in the effector secretion ‘on’ position in the absence of PcrG and PcrV (e.g. in the case of the pcrGV null mutant). The assembly of PcrV at the needle-tip (and perhaps binding of PcrG to a cytoplasmic component(s) of the T3SS [X]) shifts the conformation of the apparatus to the effector secretion ‘off’ conformation.