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. 2011 Jan 3;1(8):710–720. doi: 10.18632/oncotarget.205

Figure 1: EZH2 expression is associated with high grade glioblastoma.

Figure 1:

(A) Representative tissue sections stained with an antibody directed against EZH2. Immunohistochemical staining shows absent nuclear staining of non-neoplastic brain (NNB), and strong nuclear staining in glioblastoma (GBM). Scale bar = 100 µm. (B) Quantification of EZH2 protein expression in glioma tissue microarrays. Negative = 0%; Weak = <5%; Intermediate 5-25%; Strong = >25% positive EZH2 staining. EZH2 expression correlates to glioma grade (left) and to glioma recurrence (right). (C) Correlation between GBM patient survival and EZH2 mRNA expression, red indicates high EZH2 expression, yellow indicates low EZH2 expression and blue indicates all patients (http://caintegrator-info.nci.nih.gov/rembrandt). (D) EZH2 protein analysis by Western blot on various cell lines and non-neoplastic brain tissue (NNB).