Table 2.
Multiple-dose pharmacokinetic parameters of anidulafungin by age group.
| Subject | CLss (L/kg/h) | Vss (L/kg) | AUCss (μg*h/mL) | Cmaxss (μg/mL) | C24-ss (μg/mL) | Cmax LD (μg/mL) | C24 LD (μg/mL) |
|---|---|---|---|---|---|---|---|
| Neonates | |||||||
| 1 | 0.025 | 4.4 | 56.4 | 3.1 | 1.3 | 2.9 | 0.9 |
| 2 | 0.026 | 2.2 | 57.3 | 3.7 | 1.3 | - | - |
| 3 | 0.019 | 1.1 | 78.3 | 4.3 | 2.6 | - | - |
| 4 | 0.021 | 1.8 | 71.7 | 3.3 | 2.9 | 4 | 2.1 |
| 5 | 0.018 | 2.4 | 85.5 | 4.0 | 2.6 | - | - |
| 6 | 0.014 | 1.0 | 109.0 | 6.7 | 4.0 | 5.9 | 3.2 |
| 7 | 0.049 | 1.6 | 30.4 | 2.2 | 0.8 | 1.6 | 0.9 |
| 8 | 0.016 | 0.5 | 92.0 | 5.4 | 2.5 | 4.9 | 1.9 |
| Median | 0.020 | 1.7 | 74.9 | 3.9 | 2.6 | 4 | 1.9 |
| Range | 0.013–0.049 | 0.5–4.4 | 30.4–108.9 | 2.2–6.7 | 0.8–4.0 | 1.6–5.9 | 0.9–3.2 |
| Infants | |||||||
| 9 | 0.016 | 1.0 | 92.5 | 4.1 | 3.3 | 7.1 | 2.3 |
| 10 | 0.015 | 2.8 | 102.9 | 5.8 | 3.1 | 5 | 2.4 |
| 11 | 0.018 | 0.9 | 83.1 | 4.7 | 2.9 | 6.8 | 1.9 |
| 13 | 0.013 | 0.6 | 114.5 | 7.2 | 5.7 | 7.7 | 2.5 |
| 14 | 0.027 | 1.2 | 54.8 | 3.6 | 1.6 | 4.3 | 1.7 |
| 15 | 0.005 | 0.2 | 278.0 | 14.9 | 8.4 | 15.9 | 8.1 |
| Median | 0.015 | 0.9 | 97.7 | 5.2 | 3.2 | 6.9 | 2.3 |
| Range | 0.005–0.027 | 0.2–2.8 | 54.8–278.0 | 3.6–14.9 | 1.6–8.4 | 4.3–15.9 | 1.7–8.1 |
| Total median | 0.017 | 1.1 | 84.3 | 4.2 | 2.7 | 5.0 | 2.1 |
| Total range | 0.005–0.049 | 0.2–4.4 | 30.3–278.0 | 2.2–14.9 | 0.8–8.4 | 1.6–15.9 | 0.9–8.1 |
AUCss: Area under the curve at steady-state (0–24 h); CLss: steady-state clearance; Vss: steady-state volume of distribution; Cmax: maximum concentration; C24-ss: trough (24 h) concentration after a maintenance dose (predicted); LD: loading dose; C24 LD: trough (24 h) concentration after the loading dose. Cmax for subject #4 drawn 18 hours post dose.