Table 2C.

Histopathologic changes of the spleen in subchronic test

Group	Inflammation	Kupffer cell	Limited pale destruction	Hepatic cord destruction	Necrosis	Hepatocyte degeneration
Control	−	−	−	−	−	−
AgNO3	+	++	++	++	−	++
Nanosilver 100 μg/mL	+	+	+	+	−	+
Nanosilver 1000 μg/mL	++	++	++	++	−	++
Nanosilver 10,000 μg/mL	++	+++	+++	+++	+	+++

Notes: Severe (+++); moderate (++); mild (+); none (−).