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Size distribution and morphology of amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs). A) The mean diameter of polysorbate 80-coated AmB-PBCA-NPs determined by a Coulter Laser Granulometer was 69.0 ± 28.6 nm. B) AmB-PBCA-NPs without polysorbate 80 coating were spherical in shape. C) AmB-PBCA-NPs after polysorbate 80 modification had a more elliptical shape but were of a similar size to uncoated particles (×50,000).
