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. 2011 Apr 28;6:905–913. doi: 10.2147/IJN.S17503

Figure 2.

Figure 2

Amphotericin B (AmB) levels in various tissues following injections of AmB, amphotericin B-polybutylcyanoacrylate nanoparticles (AmB-PBCA-NPs), or amphotericin B liposome (AmB-L). A) High-performance liquid chromatogram showing the presence of AmB in brain tissue. The detection limit of AmB was 10 ng/mL, and the interday and intraday coefficients of variation were 5% or less between 5 ng/mL and 200 ng/mL. B) AmB was not detected in the brain tissue of mice treated with noncomplexed AmB but was found 30 minutes after AmB-PBCA-NP treatment and 3–6 hours after AmB-L treatment (n = 28/group). C–D) The concentration of AmB in various tissues is shown after AmB, AmB-L, and AmB-PBCA-NP treatment, respectively (n = 28). AmB was concentrated mainly in the liver; note also the higher lung concentration when using AmB-PBCA-NPs.