Figure 1.

The effects of homogenization factors on particle size and PI of CyA-loaded SPC/SDC liposomes. Typical size distribution of CyA-loaded SPC/SDC liposomes before (A) or after (B) homogenization is shown. Particle size and PI with different factors including homogenization pressure (^▴▴P < 0.01 comparing PI at 100 and 150 bar; ^▴▴▴P < 0.001 comparing PI at 100 and 150 bar) (C) and homogenization cycles (D) are shown. Data are presented as mean ± SD (n = 3).

Abbreviations: Chol, cholesterol; CyA, cyclosporine A; PI, polydispersity index; SPC, soybean phosphatidylcholine; SDC, sodium deoxycholate.