Figure 4.
Methylation of introns, exons and intron-exon junctions. A, LNCaP (left) and PrEC (right) cells show significant enrichment for DNA methylation at intron sequences. Conventions are the same as for Figure. 2A. B, The average smoothed adjusted log2(M/T) across all short (842 - 2,715 bp) and long (2715 - 11,673 bp) introns was plotted with respect to the relative intron position (as a percentage of intron length), showing generally increased average signal towards the ends of introns in LNCaP (left) and PrEC (right) cells. C - D, Identified methylated regions in LNCaP (left) and PrEC (middle) cells, and hypermethylated (right) regions in LNCaP vs. PrEC cells, were highly enriched for overlap with exons and intron-exon junctions. Conventions are the same as for Figure 2A.