Table 2.
Association between serum 25OHD concentrations and lung function, total IgE, and peripheral eosinophil count
| Q uartile of serum 25OHD concentration |
p trend | ||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | ||
| FEV1, liters | 2.0 ± 0.07 | 2.0 ± 0.07 | 2.0 ± 0.07 | 2.1 ± 0.07 | 0.03 |
| FEV1 % predicted, % | 62.9 ± 3.8 | 65.1 ± 3.7 | 72.8 ± 3.7 | 72.9 ± 3.7 | 0.02 |
| Participants with FEV1 <75% predicted, % | 81.5 | 75.0 | 79.6 | 72.5 | |
| Adjusted OR | 1 (ref.) | 0.57 (0.31–1.07) | 0.53 (0.28–1.03) | 0.50 (0.26–0.96)* | 0.007 |
| FEV1/FVC, % | 60.9 ± 1.3 | 63.2 ± 1.3 | 63.0 ± 1.3 | 66.2 ± 1.3* | 0.0005 |
| Participants with FEV1/FVC <0.75, % | 70.4 | 57.4 | 57.9 | 54.1 | |
| Adjusted OR | 1 (ref.) | 0.67 (0.32–1.39) | 0.76 (0.35–1.68) | 0.44 (0.20–0.95)* | 0.007 |
| Total IgE, kU/l | 230 ± 1.2 | 174 ± 1.2 | 234 ± 1.2 | 192 ± 1.2 | 0.50 |
| Participants with total IgE >100 kU/l, % | 81.3 | 77.8 | 81.5 | 77.9 | |
| Adjusted OR | 1 (ref.) | 0.99 (0.53–1.83) | 1.18 (0.62–2.23) | 0.91 (0.48–1.71) | 0.59 |
| Eosinophil count, × 109/l | 0.59 ± 0.06 | 0.39 ± 0.06 | 0.45 ± 0.06 | 0.46 ± 0.06 | 0.17 |
| Eosinophils, % | 7.3 ± 0.5 | 6.3 ± 0.5 | 7.0 ± 0.5 | 6.6 ± 0.5 | 0.92 |
Adjusted means ± SE. Adjusted for age (years), sex, smoking (current, past, or never), BMI (<23, 23–27, ≥27), season of blood collection, and symptom duration (years). ref. = Reference.
*
p < 0.05 relative to the lowest quartile.