Table 3. Assessed adverse events by the UKU Side Effect Rating Scale for 78 healthy first degree relatives of patients with a history of major depressive disorder following four weeks of intervention by escitalopram 10 mg (N = 39) or placebo (N = 39) in the AGENDA trial.

Adverse events	Escitalopram N (%)	Placebo N (%)	p (χ2)
Restlessness	6 (15)	9 (23)	0.39
Insomnia	2 (5)	9 (23)	0.02*
Tremor	1 (3)	1 (3)	1.00
Nausea	4 (10)	4 (10)	1.00
Diarrhoea	4 (10)	1 (3)	0.17
Sweating	6 (15)	4 (10)	0.50
Less libido	7 (18)	2 (5)	0.08
Erective dysfunction (men)	5 (13)	1 (3)	0.09
Ejaculating problems (men)	11 (28)	1 (3)	0.002*
Orgasmic dysfunction	11 (28)	0 (0)	0*
Headache	1 (3)	1 (3)	1.00