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. Author manuscript; available in PMC: 2012 May 4.
Published in final edited form as: J Am Chem Soc. 2011 Apr 7;133(17):6736–6744. doi: 10.1021/ja200222n

Figure 2.

Figure 2

Crystal structures of macrocyclic peptides mcVQIVFBr, mcAIIFL and mcLVFFA. Within the monomeric structures (a), hydrogen bonds link the blocking and recognition strands and are shown as dotted lines. β-Sheet formation by dimeric assemblies are either parallel or antiparallel as shown in (b). (c) Molecular packing of four different tetramers. The tetrameric macrocyclic molecules form a variety of β-sheet-to-β-sheet packing geometries, deviating by 0° to 45° from cross-β geometry as shown in (d).