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. 2011 Jun 27;6(6):e21452. doi: 10.1371/journal.pone.0021452

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Downs et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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GR-PRA1 appears to be recessive and fully penetrant, with the exception of one dog not yet diagnosed. Individual 29 is not clinically affected with PRA, but did show ophthalmascopic signs of the disease at the age of 6. Individuals 31 and 32 were only 4 years old when examined at the same time as a number of relatives including their mother, and were diagnosed with early-stage PRA. Individuals that formed part of the genome-wide association study are indicated with “*”.