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. 2011 Jun 27;6(6):e21563. doi: 10.1371/journal.pone.0021563

Table 1. Distributions of select variables in breast cancer cases and cancer-free controls.

Variables Stage 1 Stage 2 Combined Combined
case(N = 878) control(N = 900) case(N = 914) control(N = 967) case(N = 1792) control(N = 1867) P value
Age, year (mean ± SD) 51.29±11.38 51.47±11.67 50.11±11.36 48.64±12.28 50.69±11.38 50.01±12.07 0.077
Age at menarche, year (mean ± SD)a 15.25±1.85 15.85±1.90 15.18±1.96 16.24±1.81 15.21±1.90 16.05±1.86 <0.0001
Age at first live birth, year (mean ± SD)b 25.65±3.48 24.90±3.40 25.55±3.16 24.15±2.58 25.60±3.32 24.51±3.03 <0.0001
Age at natural menopause, year (mean ± SD)c 49.85±3.18 49.15±4.09 49.71±3.72 49.69±3.56 49.78±3.45 49.42±3.84 0.051
Menopausal status <0.0001
Premenopausal 416 437 434 530 850 967
Natural menopause 386 432 379 418 765 850
Unnatural menopause 58 16 84 9 142 25
Estrogen receptor (ER)
Positive 369 434 803
Negative 321 322 643
Progesterone receptor (PR)
Positive 396 414 810
Negative 294 340 634
a

Age at menarche information was available in 862 breast cancer cases and 896 controls (stage 1), 893 breast cancer cases and 962 controls (stage 2).

b

Age at first live birth information was available in 830 breast cancer cases and 872 controls (stage 1), 850 breast cancer cases and 943 controls (stage 2).

c

Age at natural menopause information was available in 380 breast cancer cases and 411 controls (stage 1), 363 breast cancer cases and 398 controls (stage 2).