Table 4. Stratified analysis on the associations between rs2580520 and risk of breast cancer.
| Characteristics | Case | Control | Recessive model | ||||||
| CC(%) | CG(%) | GG(%) | CC(%) | CG(%) | GG(%) | OR(95%CI)a | P | P b | |
| Age | |||||||||
| <50 | 563(63.2) | 248(27.9) | 79(8.9) | 605(61.9) | 312(31.9) | 61(6.2) | 1.53(1.06,2.20) | 0.043 | 0.668 |
| ≥50 | 553(62.1) | 251(28.2) | 86(9.7) | 514(59.6) | 303(35.2) | 45(5.2) | 1.63(1.10,2.41) | 0.014 | |
| Menopausal status | |||||||||
| Premenopausal | 526(62.1) | 242(28.6) | 79(9.3) | 589(61.4) | 314(32.8) | 56(5.8) | 1.66(1.15,2.39) | 0.007 | 0.520 |
| Postmenopausalc | 474(62.5) | 218(28.7) | 67(8.8) | 499(59.8) | 288(34.5) | 48(5.7) | 1.39(0.93,2.06) | 0.107 | |
| Age at menarche | |||||||||
| <15 | 428(62.6) | 191(27.9) | 65(9.5) | 234(59.9) | 133(34.0) | 24(6.1) | 1.63(1.00,2.66) | 0.050 | 0.848 |
| ≥15 | 669(63.1) | 302(28.5) | 89(8.4) | 879(61.0) | 480(33.3) | 82(5.7) | 1.54(1.13,2.11) | 0.007 | |
| Age at first live birth | |||||||||
| <25 | 386(63.0) | 165(26.9) | 62(10.1) | 521(57.3) | 333(36.6) | 55(6.1) | 1.70(1.15,2.51) | 0.008 | 0.467 |
| ≥25 | 661(62.5) | 311(29.5) | 84(8.0) | 569(64.6) | 263(29.8) | 49(5.6) | 1.39(0.95,2.02) | 0.091 | |
| ER status | |||||||||
| ER+ | 505(62.3) | 215(26.9) | 78(9.8) | 1.62(1.17,2.23) | 0.003 | 0.568 | |||
| ER- | 394(61.7) | 190(29.7) | 55(8.6) | 1.41(0.99,2.00) | 0.057 | ||||
| PR status | |||||||||
| PR+ | 503(62.3) | 225(27.9) | 79(9.8) | 1.61(1.17,2.21) | 0.004 | 0.585 | |||
| PR- | 392(62.4) | 182(29.0) | 54(8.6) | 1.41(0.99,2.01) | 0.055 | ||||
a
Adjusted by age, age at menarche, menopausal status where appropriate.
b
p for heterogeneity.
c
Postmenopausal status for natural menopause.