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. 2011 Jun 27;6(6):e21581. doi: 10.1371/journal.pone.0021581

Figure 3. Growth phase-dependent utilization of amino acid-metabolizing pathways in P. acnes.

Figure 3

The schematic representation includes amino acid-metabolizing enzymes whose genes were strongly deregulated between the exponential (green) and stationary (yellow) growth phases. The arginine deiminase pathway (PPA0582-0585) is an exponential phase trait, whereas the pathways for the interconversion of glutamate to ornithine (PPA1347-1350) and of glutamine/aspartate to dihydroorotate (PPA0997-1000) are stationary growth phase traits. Please note also the connected fumarate-producing reactions selectively upregulated in strain 266 (in grey). Fumarate respiration is a major source of energy conservation in P. acnes; most likely, reducing equivalents are delivered by the NADH dehydrogenase (PPA1922-1936). The enzyme-attributed numbers correspond to the gene nomenclature of the KPA genome. For simplicity reasons inorganic and organic phosphate cosubstrates were omitted from the scheme.