Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2011 Jun 27;6(6):e21630. doi: 10.1371/journal.pone.0021630

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Kaminitz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

A. Representative plots of CD25 upregulation under CD3 stimulation in splenocytes from NOD and wild type mice. Quantitative conversion to express CD25 in splenocyte cultures from NOD (n = 4) and wild type females (n = 6) under CD3 and CD3/CD28 stimulation as compared to unstimulated cultures (naïve). Other delineates all CD4⁻ cells. B. Proliferation rates of CD4⁺ T cells that upregulated CD25 expression (CD25⁻→CD25⁺) as determined from CFSE dilution in mixed cultures of splenocytes from NOD (n-4) and wild type mice (n = 5) under CD3 and CD3/CD28 stimulation. C. FasL-induced apoptosis in reference to CD25 expression in gated CD4⁺ T cells within mixed splenocyte cultures from NOD and wild type mice (n = 4) under CD3/CD28 stimulation. Apoptosis was also measured under inhibition of proliferation with Mitomycin C (n = 3).