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. Author manuscript; available in PMC: 2012 Jun 26.
Published in final edited form as: Cell. 2011 Jun 16;145(7):1142–1155. doi: 10.1016/j.cell.2011.05.024

Figure 2. Different modes of self-renewal by individual RGLs in the adult dentate gyrus.

Figure 2

(A) Time course of activation of labeled RGLs in the adult dentate gyrus after induction with the 1X dose of tamoxifen. Shown is the quantification of clones consisting of a single RGL, indicating quiescence. Values present mean ± SEM (n = 3–8 animals).

(B–F) Sample confocal images of GFP+ cells in the process of, or right after RGL cell division (Pc ≥ 99.8%). Shown are samples of neurogenic asymmetric cell division (B, D), astrogenic asymmetric cell division (C, E) and symmetric cell division (F). The potential lineage relationship is indicated in the insert. R: RGL; N: neuronal lineage; A: astroglia. Note that after cell division, the RGL and newborn astroglia returned to quiescence (MCM2−; D, E), whereas the IPC re-entered the cell cycle (MCM2+; D). Scale bars: 10 µm.

(G) A schematic diagram of three modes of self-renewal made by an RGL in the adult dentate gyrus.