Table 2. Posterior cingulate measurements in young-adult APOE ε4 carriers and non-carriers.

	Non-Carriers n = 25	Carriers+ n = 15
Number subjects with non-zero pathology score:
Aβ Immunohistochemistry	0	1
Thioflavin S	0	1
AT8 Immunohistochemistry	6 (24%)	3 (20%)
Campbell-Switzer	0	1
Amyloid ELISA (pg/mg total protein), mean ± stdev:			P
Soluble Aβ1–40	6.0 ± 6.9	4.5 ± 3.7	0.36
Insoluble Aβ1–40	3.5 ± 6.2	6.8 ± 10.3	0.29
Soluble Aβ1–42	0.0 ± 0.0	0.0 ± 0.0	–
Insoluble Aβ1–42	63.3 ± 89.6	71.8 ± 49.1	0.71
CO Activity (nmol cyt c/min/mg), mean ± stdev:
Overall	361 ± 14	352 ± 15	0.036*
Superficial Layer I	360 ± 23	340 ± 14	0.011**
External Granular Layer II	364 ± 16	349 ± 10	0.004**
External Pyramidal Layer III	371 ± 16	359 ± 12	0.053
Internal Granular Layer IV	364 ± 14	358 ± 14	NS
Internal Pyramidal Layer V	359 ± 16	354 ± 18	NS
Multiform Layer VI	347 ± 18	350 ± 26	NS

⁺The APOE ε4 carriers included 2 homozygotes and 13 heterozygotes.

APOE ε4 homozygote with significant pathology excluded (all remain nonsignificant with inclusion, p > 0.05).

^*2-tailed separate-variance t-test, p < 0.05.

^**2-tailed separate-variance t-test, p < 0.05, reported P Bonferroni-corrected for multiple comparisons.