Table 3.

Multivariable Cox proportional hazards regression analyses to evaluate predictors of biochemical recurrence and metastasis following salvage radical prostatectomy

Feature	Outcome: BCR			Outcome: Metastases
	HR	95% CI	p value	HR	95% CI	p value
Preoperative model (n = 376)
Log PSA before SRP, ng/ml	1.19	1.03–1.39	0.022	1.37	1.05–1.79	0.022
Biopsy Gleason score before SRP	–	–	<0.001	–	–	<0.001
≤6	Reference	Reference	–	Reference	Reference	–
7	2.03	1.28–3.22	–	2.77	0.97–7.94	–
≥8	3.22	2.02–5.12	–	6.88	2.57–18.40	–
Unknown/not graded	1.94	1.24–3.05	–	3.31	1.24–8.84	–
Clinical stage before SRP	–	–	0.7	–	–	0.14
T1	Reference	Reference	–	Reference	Reference	–
T2	1.18	0.78–1.78	–	2.49	0.88–7.10	–
T3	1.14	0.70–1.87	–	3.41	1.13–10.30	–
Unknown	0.92	0.53–1.60	–	1.67	0.44–6.29	–
Postoperative model (n = 372)
Log PSA before SRP, ng/ml	1.21	1.04–1.40	0.014	1.64	1.24–2.18	<0.001
Pathologic Gleason score at SRP	–	–	<0.001	–	–	<0.001
≤6	Reference	Reference	–	Reference	Reference	–
7	1.48	0.89–2.48	–	0.68	0.27–1.76	–
≥8	2.64	1.55–4.50	–	2.70	1.11–6.56	–
Unknown/not graded	1.47	0.85–2.51	–	0.95	0.37–2.44	–
EPE	1.06	0.76–1.47	0.7	1.53	0.84–2.79	0.17
SVI	1.26	0.89–1.79	0.19	1.18	0.65–2.14	0.6
LNI	1.10	0.75–1.61	0.6	2.04	1.14–3.67	0.017

BCR = biochemical recurrence; HR = hazard ratio; CI = confidence interval; PSA = prostate-specific antigen; SRP = salvage radical prostatectomy; EPE = extraprostatic extension; SVI = seminal vesical invasion; LNI = lymph node involvement.