Table 4.
Univariate Cox proportional hazards regression analyses to evaluate predictors of death from prostate cancer following salvage radical prostatectomy
| Feature | Outcome: Death from PCa | ||
|---|---|---|---|
| HR | 95% CI | p value | |
| Log PSA before SRP, ng/m | 1.85 | 1.32–2.60 | <0.001 |
|
| |||
| Biopsy Gleason score before SRP | |||
| ≤6 | Reference | Reference | 0.04 |
| 7 | 4.14 | 1.12–15.40 | – |
| ≥8 | 8.09 | 2.25–29.10 | – |
| Unknown/not graded | 4.03 | 1.16–14.00 | – |
|
| |||
| Clinical stage before SRP | |||
| T1 | Reference | Reference | 0.03 |
| T2 | 5.81 | 0.78–43.40 | – |
| T3 | 10.60 | 1.39–80.60 | – |
| Unknown | 1.74 | 0.16–19.30 | – |
|
| |||
| Pathology Gleason score at SRP | |||
| ≤6 | Reference | Reference | 0.003 |
| 7 | 0.68 | 0.20–2.22 | – |
| ≥8 | 3.43 | 1.22–9.64 | – |
| Unknown/not graded | 1.87 | 0.67–5.20 | – |
|
| |||
| EPE | 1.67 | 0.85–3.28 | 0.14 |
|
| |||
| SVI | 2.22 | 1.17–4.21 | 0.015 |
|
| |||
| LNI | 1.30 | 0.60–2.84 | 0.5 |
|
| |||
| PSM | 1.80 | 0.96–3.37 | 0.068 |
PCa = prostate cancer; PSA = prostate-specific antigen; SRP = salvage radical prostatectomy; CI = confidence interval; EPE = extraprostatic extension; SVI = seminal vesical invasion; LNI = lymph node involvement; PSM = positive surgical margins.