With the test set built by Wang,41 binding affinity comparison was done for LISA and some well-known scoring functions, ITScore/SE,20 ITScore,19 X-Score,5 DFIRE,42 DrugScoreCSD,18 DrugScorePDB,15 Cerius2/PLP,43,44 SYBYL/G-Score,45 SYBYL/D-Score,46 SYBYL/ChemScore,47 Cerius2/PMF,12 DOCK/FF,46 Cerius2/LUDI,31,48 Cerius2/LigScore,49 SYBYL/F-Score,50 AutoDock.51