Table 1.

Colon biopsies from patients with acute E. histolytica colitis were obtained from the sigmoid colon in an area of ulceration. Convalescent biopsies for comparison were obtained from the same patient 60 days later. RNA from colonic biopsy samples was isolated simultaneously from the same sample for microarray and RT-qPCR. (A) Comparison of microarray and (B) RT-qPCR REG 1A and REG 1B mRNA expression between colon biopsy samples from individuals with acute E. histolytica diarrhea (day 1) versus convalescence (day 60)

	Day 1 mean expression (Log2) (±SEM)	Day 60 mean expression (Log2) (±SEM)	Fold change	p-value
REG 1A	10.69 (0.76)	7.8 (0.22)	7.4	0.003
REG 1B	9 (1.02)	5.59 (0.23)	10.65	0.006
(A)

	Day 1 normalized CT mean (±SEM)	Day 60 normalized CT mean (±SEM)	CT change mean (SEM)	Expression Ratio (Day 1 /Day 60)	p-value
REG 1A	3.93 (0.86)	9.98 (0.96)	-6.05(1.29)	66.3	<0.001
REG 1B	4.07 (0.86)	9.04 (0.96)	-4.97 (1.29)	31.3	0.001
(B)