Table 1.
Incidence | Onset (mean ± SEM) | Maximal Score | Mean Score** | |
---|---|---|---|---|
* SLP-76control | 10/12 | 15.5 ± 0.7 | 4 | 1.8 ± 0.3 |
SLP-76cKO | 0/13 | N/A | 0 | 0 |
Combined data from a total of three individual experiments
The SLP-76control group includes CreT2− and non-transgenic mice in addition to SLP-76cHET
assessed at day 21 ± SEM; two-tailed student t-test was performed for comparison between SLP-76WT and SLP-76CKO mice assessed at day 21 (p < 0.0001)
Disease severity was scored on a scale of 0 – 5: 0, no illness; 1, limp tail; 2, hindlimb paresis; 3, partial hindlimb paralysis; 4, complete hindlimb paralysis; 5, moribund or dead.