Table 1.
BoNT/B | ip LD50 (ng/kg)b | Oral LD50 (μg/kg)b |
---|---|---|
Holotoxin (150kDa) | 0.33 ± 0.03 | NDc |
Complex | 1.1 ± 0.17 | 1.0 ± 0.15 |
Holotoxin in complexa | 0.33 ± 0.05 | 0.29 ± 0.043 |
LD50 value of BoNT/B complex was normalized to holotoxin content. BoNT/B holotoxin constituted about 28.5% of total protein content.
Mean ± S.E.M, n ≥8.
ND: not determined