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. 2011 Jun 1;31(22):7991–8000. doi: 10.1523/JNEUROSCI.6650-10.2011

Figure 5.

Figure 5.

Effect of background light on cone operating range in control and GCAPs−/− retinas. Maximum cone response amplitudes under a series of background lights were measured 2 s after the onset of step light illumination in control (A) and GCAPs−/− (B) retinas by a test flash of unattenuated white light. The time course of light stimulation is shown on the top of each panel. The step light intensities (photons μm−2 s−1) were 0, 440, 1.3 × 103, 3.9 × 103, 1.2 × 104, 5.2 × 104, and 1.7 × 105 for control retina and 0, 130, 440, 1.3 × 103, 3.9 × 103, 1.2 × 104, and 5.2 × 104 for GCAPs−/− retina. C, Normalized maximum cone responses as a function of background intensity for control (filled circles) and GCAPs−/− (open circles) retina. The smooth curves represent best-fitted Hill equation (Eq. 2) with k = 0.47 and 0.70, IR = 94,300 and 3900 photons μm−2 s−1 for control and GCAPs−/−, respectively. Error bars show SEM. The dashed and dotted curves represent the expected change in maximum response of control and GCAPs−/− cones, respectively, in the absence of adaptation (Eq. 4). (Inset) Normalized maximum cone response as a function of background intensity for control (n = 5) and GCAPs−/− (n = 5) cones obtained with single-cell recordings. The curves represent best-fitted Hill equations with k = 0.49 and 0.78, IR = 3.4 × 105 and 1.2 × 104 photons μm−2 s−1 for control and GCAPs−/− cones, respectively.