Table 3.
Conservation of critical enzymes from S. purpuratus to Homo sapiens
| Enzyme name | Percent identities | Percent similarity |
|---|---|---|
| HMG-CoA reductase | 58.0% (530/903) | 72.0% (657/903) |
| Sterol-sensing domain (SSD) | 68.4% | |
| HMG-CoA reductases family domain | 68.6% | |
| Squalene synthase (urchin hypothetical protein LOC586013) | 60.0% (246/404) | 78.0% (319/404) |
| Squalene and phytoene synthases signature 1 | 93.8% | |
| Squalene and phytoene synthases signature 2 | 84.6% | |
| PLC | 61.0% (736/1191) | 76.0% (915/1191) |
| PH domain | 38.0% | |
| C2 domain | 44.4% | |
| PI-3 kinase (urchin hypothetical protein XP_001193595.1) | 41.0% (460/1101) | 60.0% (664/1101) |
| PI-3 and 4 kinases family domain | 70.4% | |
| PX domain | 42.7% | |
| C2 domain | 57.8% |