Liraglutide n =1363 | Exenatide n =231 | Placebo n =524 | |
---|---|---|---|
Cardiovascular risk markers, relative change (%) | |||
Brain natriuretic peptide | −11.9* | −3.9 | 1.4 |
High-sensitivity C-reactive protein | −23.1† | −15.6* | −3.0 |
Lipids, change (mg/dL) | |||
Total cholesterol | −2.3* | −0.9 | 0.2 |
LDL-cholesterol | −3.6† | −2.7‡ | −2.3‡ |
HDL-cholesterol | −0.7† | −0.9* | −0.5‡ |
Triglycerides | −3.6* | −0.9 | −0.4 |
*P<0.01 vs. baseline.
†P<0.001 vs. baseline.
‡P<0.05 vs. baseline.
HDL=high-density lipoprotein; LDL=low-density lipoprotein.
Adapted with permission from: Plutzky J, Garber A, Falahati A, Taft AD, Paultzer NR. Reductions in lipids and CV risk markers in patients with type 2 diabetes treated with liraglutide: a meta-analysis. 20th World Diabetes Congress; October 18–22, 2009; Montreal, Canada. Abstract O-0542. Available at: http://www.diabetes.ca. Accessed August 15, 2009.