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. Author manuscript; available in PMC: 2012 Jun 3.
Published in final edited form as: J Biomech. 2011 Apr 8;44(9):1654–1659. doi: 10.1016/j.jbiomech.2011.03.026

Figure 1.

Figure 1

Ratio cö of internal to external solute concentration over time in cartilage disks for (A) 70 kDa dextran, (B) 10 kDa dextran, (C) 3 kDa dextran, (D) fluorescein (332 Da), and (E) transferrin (80 kDa) under dynamic loading (DL) and unloaded passive diffusion (PD) conditions (mean ± standard deviation). Results demonstrate that DL progressively pumps solutes into cartilage at concentrations that significantly exceed those achieved under PD; this pumping mechanism is most effective for larger molecular weight solutes, but insignificant for unconjugated fluorescein. *p<0.02: significant increase above respective PD time point. +p<0.001, †p<0.05: significant increase above initial DL time point.