Table 1.

APC Cytokine Secretion from WT and p47^phox-/- Mice Cultured with 1 × 10⁸ CFUs/mL of UVi Pn or Lm for 24 Hours in Vitro

Variable	IL-6		IL-12		TNF-α
	WT	p47phox-/-	WT	p47phox-/-	WT	p47phox-/-
BMDCs
Pn	5.68 ± 0.63	10.27 ± 0.88⁎	1.25 ± 0.04	1.37 ± 0.06	ND	0.89 ± 0.03
Lm	24.39 ± 0.63	21.24 ± 0.88	3.12 ± 0.14	4.82 ± 0.03†	5.25 ± 0.30	3.62 ± 0.50
Medium	0.625 ± 0.03	0.646 ± 0.002	0.263 ± 0.001	0.237 ± 0.57	ND	0.393 ± 0.17
BMMs (M-CSF)
Pn	0.75 ± 0.09	2.05 ± 0.08†	1.40 ± 0.09	4.70 ± 0.10†	ND	1.84 ± 0.09
Lm	2.81 ± 0.39	5.16 ± 0.33⁎	1.89 ± 0.07	6.43 ± 0.12†	1.50 ± 0.20	3.87 ± 0.14†
Medium	ND	ND	ND	ND	ND	1.42 ± 0.38

Data are given as mean ± SEM (in ng/mL). n = 4. Concentrations of IL-6, IL-12, and TNF-α in the culture supernatant were determined by ELISA. The limit of detection for IL-6 was <31 pg/mL; IL-12, <62 pg/mL; and TNF-α, <250 pg/mL.

ND, not detectable.

^⁎P = 0.04.

^†P = 0.0004.

Data are from Vasilevsky et al.¹⁹