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. Author manuscript; available in PMC: 2011 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2010 Jun 12;126(1):127–32.e7. doi: 10.1016/j.jaci.2010.04.026

FIG 1.

FIG 1

Impaired TLR-induced NF-κB–dependent cytokine production by patient PBMCs. PBMCs were incubated with medium or TLR ligands for 24 hours, and TNF-α (A) and IFN-α (B) were quantified. Graphs show the mean and SD of 4 independent experiments using PBMCs from the index patient and healthy controls (n = 4). *P < .05; ***P < .001. C, TNF-α production in PBMCs from the patient’s affected brother. PMA, Phorbol 12-myristate 13-acetate.