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Decreased NEMO protein and mRNA levels in the patient. Western blots from PBMC lysates from control, index patient, affected brother, and unaffected mother (A) and EBV B-cell lysates (B). C, Scanning densitometry of NEMO protein levels for each EBV B cell line, normalized to actin. Controls arbitrarily set to 1. D, qPCR analysis of NEMO mRNA levels, normalized to GAPDH, in EBV B-cell lines from index patient, brother, and 8 controls. Bar represents the mean. Dashed lines span the 95% CI.
