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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Behav Pharmacol. 2011 Jun;22(3):248–261. doi: 10.1097/FBP.0b013e328345f90d

Figure 2. The effects of M100907 in combination with cocaine administration on behavioral disinhibition measured with the DRL-20 sec task.

Figure 2

Response rate (A) and number of reinforcers (0.25 sec water deliveries) obtained (B) on the DRL-20 s task test day are presented as % of control (vehicle+saline) treatment (mean ± SEM). (C) The relative frequency (frequency of inter-response time/total number of responses ± SEM) of a given inter-response interval for control and cocaine alone or M100907 (0.3 mg/kg) + cocaine is represented as a single point for each 2-s time bin. M100907 (0.01, 0.03, 0.1, 0.3, 0.5 mg/kg) was administered 15 min prior to vehicle or cocaine injections; vehicle (1 mL/kg saline or 1% Tween 80) or cocaine (10 mg/kg) was administered immediately before DRL-20 sec task test sessions in a counterbalanced within-subjects design. “←” Represents the peak shift for cocaine versus the control peak relative frequency; “→” represents the peak shift for 0.3 mg/kg M100907 + cocaine versus cocaine peak relative frequency. Statistical comparisons of descriptive statistics for the inter-response time distributions can be found in Table 2. *p<0.05 vs. control ^p<0.05 vs. vehicle+cocaine (one way repeated measures ANOVA with Dunnett’s procedure)